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Mark J. Pettenati, Ph.D.

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    336-716-WAKE

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Mark J. Pettenati, Ph.D.

Mark J. Pettenati, Ph.D.

Professor, Pathology

Comprehensive Cancer Center

Institute for Regenerative Medicine

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contactCONTACT & REFERRAL

Contact Information

Memberships

  • North Carolina Medical Genetic

  • Calgb Cytogenetics Committee

  • Cancer & Acute Leukemia Group

  • Childrens' Oncology Group

  • NPI: 1255488649

Clinical Interests

  • Genetics, Cytogenetics, Chromosomes

Education & Training

  • B.S.

    1978 - St Bonaventure University

  • Ph.D.

    1983 - West Virginia University

  • Fellowship

    1985 - Indiana University School of M

  • Fellowship

    1986 - University of Chicago Pritzker

contactRESEARCH

Research Contact Information

Research Interests

  • Translocation, Genetic, Leukemia, Myeloid, Acute, Leukemia, Myeloid, Chromosome Inversion, In Situ Hybridization, Fluorescence

Recent Publications

  • Pdx1 and controlled culture conditions induced differentiation of human amniotic fluid-derived stem cells to insulin-producing clusters Chun SY, Mack DL, Moorefield E, Oh SH, Kwon TG, Pettenati MJ, Yoo JJ, Coppi PD, Atala A, Soker S.. J Tissue Eng Regen Med. 2015;9(5):540-549.
  • Clinicopathological analysis of near-tetraploidy/tetraploidy acute myeloid leukaemia Pang CS, Pettenati MJ, Pardee TS.. J Clin Pathol. 2015;68(3):236-240.
  • Donor-derived myeloid sarcoma in two kidney transplant recipients from a single donor Palanisamy A, Persad P, Koty PP, Douglas LL, Stratta RJ, Rogers J, Reeves-Daniel AM, Orlando G, Farney AC, Beaty MW, Pettenati MJ, Iskandar SS, Grier DD, Kaczmorski SA, Doares WH, Gautreaux MD, Freedman BI, Powell BL.. Case Rep Nephrol. 2015;2015():821346.
  • A rare case of extraskeletal small cell osteosarcoma: cytohistologic correlation and review of the literature [abstract] Philip JKSS, Qasem S, Cappellari J, Pettenati M.. Am J Clin Pathol. 2015;144(Suppl 2):A100.
  • MDM2 copy numbers in well-differentiated and dedifferentiated liposarcoma: characterizing progression to high-grade tumors Ware PL, Snow AN, Gvalani M, Pettenati MJ, Qasem SA.. Am J Clin Pathol. 2014;141(3):334-341.
  • inv(16)/t(16;16) acute myeloid leukemia with non-type A CBFB-MYH11 fusions associate with distinct clinical and genetic features and lack KIT mutations Schwind S, Edwards CG, Nicolet D, Mrozek K, Maharry K, Wu YZ, Paschka P, Eisfeld AK, Hoellerbauer P, Becker H, Metzeler KH, Curfman J, Kohlschmidt J, Prior TW, Kolitz JE, Blum W, Pettenati MJ, Dal Cin P, Carroll AJ, Caligiuri MA,.. Blood. 2013;121(2):385-391.
  • New recurrent balanced translocations in acute myeloid leukemia and myelodysplastic syndromes: cancer and leukemia group B 8461 Walker A, Mrozek K, Kohlschmidt J, Rao KW, Pettenati MJ, Sterling LJ, Marcucci G, Carroll AJ, Bloomfield CD.. Genes Chromosomes Cancer. 2013;52(4):385-401.
  • Biclonal light chain gammopathy with aberrant CD33 expression in secondary plasma cell leukemia Gentry M, Pettenati M, Pang CS.. Int J Clin Exp Pathol. 2013;6(10):2224-2229.
  • Near-tetraploid/tetraploid acute myeloid leukemia: morphologic, cytogenetic, and prognostic features [abstract] Manny JS, Pardee T, Pettenati M, Pang CS.. Mod Pathol. 2012;25(Suppl 2):354A.
  • MDM2 copy numbers in well differentiated and dedifferentiated liposarcoma: where do we draw the line? [abstract] Ware P, Snow A, Pettenati M, Qasem S.. Mod Pathol. 2012;25(Suppl 2):22A.
  • Prognostic significance of the European LeukemiaNet standardized system for reporting cytogenetic and molecular alterations in adults with acute myeloid leukemia Mrozek K, Marcucci G, Nicolet D, Maharry KS, Becker H, Whitman SP, Metzeler KH, Schwind S, Wu YZ, Kohlschmidt J, Pettenati MJ, Heerema NA, Block AW, Patil SR, Baer MR, Kolitz JE, Moore JO, Carroll AJ, Stone RM, Larson RA, Bloomfield CD.. J Clin Oncol. 2012;30(36):4515-4523.
  • The first case described: monozygotic twin sisters with the fragile X premutation but with a different phenotype for premature ovarian failure Johnston-MacAnanny EB, Koty P, Pettenati M, Brady M, Yalcinkaya TM, Schmidt DW.. Fertil Steril. 2011;95(7):2431.e13-5.
  • Cytogenetic, molecular and clinical features associated with rare CBFB-MYH11 fusion transcripts in patients (Pts) with acute myeloid leukemia (AML) and inv(16)/t(16;16 [abstract] Edwards CG, Maharry K, Mrozek K, Schwind S, Paschka P, Nicolet D, Kohlschmidt J, Prior TW, Wu Y-Z, Kolitz JE, Blum W, Pettenati MJ, Cin PD, Carroll AJ, Caligiuri MA, Larson RA, Marcucci G, Bloomfield CD.. Blood. 2011;118(21):1077.
  • Prognostic utility of the European LeukemiaNet (ELN) genetic-risk classification in adults with de novo acute myeloid leukemia (AML): a study of 1,550 patients (Pts) [abstract] Mrozek K, Marcucci G, Maharry K, Nicolet D, Becker H, Whitman SP, Metzeler KH, Schwind S, Wu Y-Z, Kohlschmidt J, Pettenati MJ, Koduru PRK, Heerema NA, Block AW, Patil SR, Baer MR, Kolitz JE, Moore JO, Carroll AJ, Larson RA, Bloomfield CD.. Blood. 2011;118(21 Suppl):190-191.
  • A single institution analysis of incidence of recurrent chromosomal abnormalities in adult ALL patients according to race, gender, and age [abstract] Chiou V, Tiegs J, Isom S, Pettenati MJ, Lyerly S, Ellis LR, Pardee T, Dmitriy B, Powell BL, Levitan DA.. Blood. 2011;118(21):4869.
  • Is relapse of mantle cell lymphoma (MCL) preceded by an 'in situ' pattern in an otherwise reactive lymph node in a patient with history of MCL? Pang CS, Pettenati MJ, Manavi C, Zamkoff KW.. J Hematopathol. 2011;4():221-225.
  • Possible role of engraftment syndrome and autologous graft-versus-host disease in myelodysplastic syndrome after autologous stem cell transplantations: retrospective analysis and review of the literature Keung YK, Beaty MW, Pettenati M, Levitan D, Hurd DD.. Clin Lymphoma Myeloma Leuk. 2010;10(2):129-133.
  • Possible role of engraftment syndrome in myelodysplastic syndrome after autologous transplants [abstract] Beaty MW, Pettenati M, Hurd DH [sic] [Hurd DD], Keung Y.. Mod Pathol. 2009;22(Suppl 1):1161.
  • The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies Korbel JO, Tirosh-Wagner T, Urban AE, Chen X-N, Kasowski M, Dai L, Grubert F, Erdman C, Gao MC, Pettenati MJ, et al.. Proc Natl Acad Sci U S A. 2009;106(29):12031-36.
  • Prognostic significance of unbalanced chromosome abnormalities used by 2008 World Health Organization (WHO) classification to define 'acute myeloid leukemia (AML) with myelodysplasia- Mrozek K, Holland KB, Pettenati MJ, Maharry K, Marcucci G, Baer MR, Kolitz JE, Margeson D, Edwards CG, Carroll AJ, et al.. Blood. 2009;114(22):1021.
  • Possible role of engraftment syndrome in myelodysplastic syndrome after autologous transplants [abstract] Keung Y, Beaty MW, Pettenati M, Levitan D, Molnar I, Thakuri M, Cruz J, Hurd DD.. J Clin Oncol. 2008;26(Suppl):a18016.
  • Central review of cytogenetics is necessary for cooperative group correlative and clinical studies of adult acute leukemia: the Cancer and Leukemia Group B experience Mrozek K, Carroll AJ, Maharry K, Rao KW, Patil SR, Pettenati MJ, Watson MS, Arthur DC, Tantravahi R, Heerema NA, et al.. Int J Oncol. 2008;33(2):239-244.
  • Effects of mutant human Ki-rasG12C gene dosage on murine lung tumorigenesis and signaling to its downstream effectors Dance-Barnes ST, Kock ND, Floyd HS, Moore JE, Mosley LJ, D'Agostino RB Jr, Pettenati MJ, Miller MS.. Toxicol Appl Pharmacol. 2008;231(1):77-84.
  • Possible role of engraftment syndrome in myelodysplastic syndrome after autologous transplants [abstract] Keung YK, Beaty MW, Pettenati M, Levitan D, Molnar I, Thakuri MC, Cruz J, Hurd DD.. Blood. 2008;112(11):751.
  • Recurring translocation (10;17) and deletion (14q) in clear cell sarcoma of the kidney Brownlee NA, Perkins LA, Stewart W, Jackle B, Pettenati MJ, Koty PP, Iskandar SS, Garvin AJ.. Arch Pathol Lab Med. 2007;131(3):446-451.
  • Antimetabolite therapy for lesser-risk B-lineage acute lymphoblastic leukemia of childhood: a report from Children's Oncology Group Study P9201 Chauvenet AR, Martin PL, Devidas M, Linda SB, Bell BA, Kurtzberg J, Pullen J, Pettenati MJ, Carroll AJ, Shuster JJ, et al.. Blood. 2007;110(4):1105-1111.
  • Specific extra chromosomes occur in a modal number dependent pattern in pediatric acute lymphoblastic leukemia Heerema NA, Raimondi SC, Anderson JR, Biegel J, Camitta BM, Cooley LD, Gaynon PS, Hirsch B, Magenis RE, Pettenati MJ, et al.. Genes Chromosomes Cancer. 2007;46(7):684-693.
  • Diagnosis of Burkitt lymphoma in pediatric patients by thoracentesis McLean TW, Farber RS, Lewis ZT, Wofford MM, Pettenati MJ, Pranikoff T, Chauvenet AR.. Pediatr Blood Cancer. 2007;49(1):90-92.
  • Genetic dissection using a novel whole genome tiling path BAC array reveals dramatic heterogeneity in Toriello-Carey syndrome, including a novel microdeletion syndrome at 22q12 [abstract] Hatchwell E, Tegay DH, Wang C, O'Brien JE, Allen W, Tan T, Prucka S, Pettenati MJ, Montagna C, Nowak MJ, et al.. Cell Oncol. 2007;29(2):143.
  • Two distinct subsets of dic(9;12)(p12;p11.2) among children with B-cell precursor acute lymphoblastic leukemia (ALL): PAX5-ETV6 and ETV6-RUNX1 rearrangements: a report from the Children's Oncology Group [abstract] Gastier-Foster JM, Carroll AJ, Ell D, Harvey R, Chen IM, Ketterling R, Meloni-Ehring A, Opheim KE, Pettenati M, et al.. Blood. 2007;110(11 Pt 1):431A.
  • Addition of sargramostim (GM-CSF) to imatinib results in major cytogenetic response in a patient with chronic myeloid leukemia Connor RF, Hurd D, Pettenati MJ, Koty P, Molnar I.. Leuk Res. 2006;30(10):1249-1252.
  • Pretreatment cytogenetics add to other prognostic factors predicting complete remission and long-term outcome in patients 60 years of age or older with acute myeloid leukemia: results from Cancer and Leukemia Group B 8461 Farag SS, Archer KJ, Mrozek K, Ruppert AS, Carroll AJ, Vardiman JW, Pettenati MJ, Baer MR, Qumsiyeh MB, Koduru PR, et al.. Blood. 2006;108(1):63-73.
  • Redefining the risks of prenatally ascertained supernumerary marker chromosomes: a collaborative study Graf MD, Christ L, Mascarello JT, Mowrey P, Pettenati M, Stetten G, Storto P, Surti U, Van Dyke DL, Vance GH, et al.. J Med Genet. 2006;43(8):660-664.
  • Diagnostic pitfalls associated with fine-needle aspiration biopsy in a patient with the myxoid variant of monophasic fibrous synovial sarcoma Bergman S, Brownlee NA, Geisinger KR, Ward WG, Pettenati MJ, Koty P, Ellis E, Beaty MW, Kilpatrick SE.. Diagn Cytopathol. 2006;34(11):761-767.
  • i(9q) in ALL (isochromosome 9q in precursor B-cell acute lymphoblastic leukemia) Brownlee NA, Koty P, Buss DH, Pettenati MJ.. Atlas Genet Cytogenet Oncol Haematol. 2006;10(4):589-592.
  • +10 or trisomy 10 (solely) - updated Lewis ZT, Koty PP, Pettenati MJ.. Atlas Genet Cytogenet Oncol Haematol. 2006;10(4):593-597.

All Publications

For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.

For a list of earlier publications, visit the Carpenter Library Publication Search.

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We're sorry, Dr. Pettenati is not currently accepting new patients. If you are an existing patient, you may contact the office directly at 336-716-4311.

  • Find a Pediatric Specialist
  • New Patient Appointments

    Locally

    336-716-WAKE

    Toll-free

    888-716-WAKE

  • Additional Information

    For returning patient appointments, contact the clinic directly.